nr1h4 Phenotypes

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Phenotypes

Gene Literature (6)

Nucleotides (49)

Interactants (136)

XB-GENEPAGE-487941

Gene Symbol: nr1h4 Gene Name: nuclear receptor subfamily 1 group H member 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: nr1h4 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (9 sources): Cirrhosis, Edema, Elevated circulating hepatic transaminase concentration, Failure to thrive, Hepatic failure, Hyperammonemia, Hypoglycemia, Jaundice, Prolonged prothrombin time
Mouse (43 sources): abnormal bile composition, abnormal bile salt homeostasis, abnormal bile salt level, abnormal bile secretion, abnormal blood homeostasis, abnormal hepatocyte morphology, abnormal liver perisinusoidal space morphology, abnormal liver sinusoid morphology, decreased bone mineral content, decreased circulating free fatty acids level, decreased circulating glucose level, decreased epididymal fat pad weight, decreased interscapular fat pad weight, decreased mean corpuscular volume, decreased retroperitoneal fat pad weight, decreased susceptibility to weight gain, decreased white fat cell size, enlarged cecum, enlarged gallbladder, focal hepatic necrosis, growth/size/body region phenotype, homeostasis/metabolism phenotype, increased bile salt level, increased circulating alanine transaminase level, increased circulating alkaline phosphatase level, increased circulating aspartate transaminase level, increased circulating phospholipid level, increased energy expenditure, increased fluid intake, increased food intake, increased hepatocellular carcinoma incidence, increased hepatocyte apoptosis, increased hepatocyte proliferation, increased lactate dehydrogenase level, increased liver adenoma incidence, increased liver cholesterol level, increased liver triglyceride level, increased liver tumor incidence, increased liver weight, increased sensitivity to induced morbidity/mortality, increased spleen weight, increased startle reflex, integument phenotype [+]
View all ortholog results at Monarch