tbp Phenotypes

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Phenotypes

Gene Literature (90)

Nucleotides (223)

Interactants (339)

XB-GENEPAGE-488469

Gene Symbol: tbp Gene Name: TATA-box binding protein

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tbp manipulated (1 source), tbp assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tbp KD+ tbpl2 KD+ tbpl1 KD (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (45 sources): Abnormal pyramidal sign, Aggressive behavior, Apraxia, Ataxia, Atrophy/Degeneration affecting the brainstem, Behavioral abnormality, Blepharospasm, Bradykinesia, Broad-based gait, Cerebellar Purkinje layer atrophy, Cerebellar atrophy, Chorea, Confusion, Depression, Diffuse cerebral atrophy, Dysarthria, Dysmetria, Dysphagia, Dystonia, Frontal lobe dementia, Frontal release signs, Gait ataxia, Gait disturbance, Gaze-evoked nystagmus, Generalized cerebral atrophy/hypoplasia, Gliosis, Hallucinations, Impaired pursuit initiation and maintenance, Intention tremor, Involuntary movements, Lack of insight, Limb ataxia, Mental deterioration, Mutism, Myoclonus, Neuronal loss in central nervous system, Paranoia, Parkinsonism, Positive Romberg sign, Rigidity, Seizure, Spasticity, Torticollis, Urinary incontinence, Writer's cramp [+]
Mouse (20 sources): Purkinje cell degeneration, abnormal Purkinje cell dendrite morphology, abnormal blood coagulation, abnormal nest building behavior, decreased body size, decreased locomotor activity, embryonic growth arrest, embryonic lethality at implantation, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, fetal growth retardation, hemophagocytosis, hunched posture, impaired balance, limb grasping, placenta hemorrhage, postnatal lethality, incomplete penetrance, premature death, short stride length, slow postnatal weight gain, thin cerebellar molecular layer [+]
View all ortholog results at Monarch