nedd4l Phenotypes

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Phenotypes

Gene Literature (64)

Nucleotides (488)

Interactants (350)

XB-GENEPAGE-489247

Gene Symbol: nedd4l Gene Name: NEDD4 like E3 ubiquitin protein ligase

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (34 sources): 2-3 toe syndactyly, Abnormal bleeding, Abnormal facial shape, Abnormal heart valve morphology, Abnormal nervous system morphology, Absent speech, Aortic aneurysm, Aortic regurgitation, Axial hypotonia, Cleft palate, Cortical dysplasia, Cryptorchidism, Flexion contracture, Focal-onset seizure, Gastroesophageal reflux, Global developmental delay, Gray matter heterotopia, Hearing impairment, Hernia, Hypoplasia of the corpus callosum, Intellectual disability, Joint hypermobility, Micrognathia, Optic atrophy, Patellar dislocation, Patent ductus arteriosus, Periventricular heterotopia, Periventricular nodular heterotopia, Pyloric stenosis, Scoliosis, Seizure, Shoulder dislocation, Strabismus, Thin skin [+]
Mouse (27 sources): abnormal locomotor activation, abnormal prepulse inhibition, abnormal pulmonary alveolus morphology, abnormal renal tubule morphology, abnormal startle reflex, abnormal systemic arterial blood pressure, abnormal tracheal ciliated epithelium morphology, decreased cardiac muscle contractility, decreased intestinal epithelial sodium ion transmembrane transport, decreased locomotor activity, decreased prepulse inhibition, decreased startle reflex, decreased urine osmolality, increased anxiety-related response, increased fluid intake, increased left ventricle weight, increased mean systemic arterial blood pressure, increased neutrophil cell number, increased respiratory mucosa goblet cell number, neonatal lethality, incomplete penetrance, postnatal lethality, complete penetrance, premature death, preweaning lethality, incomplete penetrance, primary atelectasis, pulmonary epithelial necrosis, respiratory system phenotype, salt-sensitive hypertension [+]
View all ortholog results at Monarch