| Monarch Ortholog Phenotypes
|
Human (67 sources):
Abnormal bleeding,
Abnormal circulating interleukin concentration,
Abnormal circulating vitamin B12 concentration,
Abnormal proportion of CD4-positive T cells,
Abnormal proportion of CD8-positive T cells,
Antineutrophil antibody positivity,
Antinuclear antibody positivity,
Antiphospholipid antibody positivity,
Arthritis,
Autoimmune hemolytic anemia,
Autoimmune thrombocytopenia,
Autoimmunity,
B-cell lymphoma,
Basal cell carcinoma,
Bone marrow hypercellularity,
Bone marrow hypocellularity,
Bruising susceptibility,
Burkitt lymphoma,
Chronic noninfectious lymphadenopathy,
Colitis,
Coombs-positive hemolytic anemia,
Decreased circulating IgG level,
Decreased circulating total IgM,
Decreased proportion of CD4-positive helper T cells,
Decreased specific anti-polysaccharide antibody level,
Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells,
Eosinophilia,
Fibroadenoma of the breast,
Gastritis,
Glomerulonephritis,
Headache,
Hepatitis,
Hepatocellular carcinoma,
Hepatomegaly,
Hodgkin lymphoma,
Hydrops fetalis,
Hypersplenism,
Increased B cell count,
Increased circulating IgA level,
Increased circulating IgE level,
Increased circulating IgG level,
Increased circulating antibody level,
Lymphadenopathy,
Lymphocytosis,
Lymphopenia,
Neoplasm of the skin,
Neoplasm of the tongue,
Neutropenia in presence of anti-neutropil antibodies,
Non-Hodgkin lymphoma,
Panniculitis,
Premature ovarian insufficiency,
Pulmonary fibrosis,
Pulmonary infiltrates,
Recurrent aphthous stomatitis,
Renal insufficiency,
Reticulocytosis,
Rheumatoid factor positive,
Seizure,
Splenomegaly,
Systemic lupus erythematosus,
T-cell lymphoma,
Thyroid adenoma,
Thyroid carcinoma,
Thyroiditis,
Urticaria,
Uveitis,
Vasculitis
[+]
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Mouse (35 sources):
abnormal CD4-positive T cell differentiation,
abnormal CD4-positive, alpha beta T cell morphology,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal T cell differentiation,
abnormal double-positive T cell morphology,
abnormal humoral immune response,
abnormal immune system organ morphology,
abnormal positive T cell selection,
abnormal renal glomerular capsule morphology,
abnormal renal glomerulus morphology,
autoimmune response,
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
decreased CD4-positive, alpha beta T cell number,
decreased CD8-positive, naive alpha-beta T cell number,
decreased T cell proliferation,
decreased single-positive T cell number,
decreased thymocyte number,
enlarged lymph nodes,
immune system phenotype,
increased B-1b cell number,
increased CD4-positive, alpha-beta memory T cell number,
increased CD8-positive, alpha-beta memory T cell number,
increased IgG1 level,
increased NK cell number,
increased anti-nuclear antigen antibody level,
increased autoantibody level,
increased central memory CD4-positive, alpha-beta T cell number,
increased central memory CD8 positive, alpha-beta T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased effector memory CD8-positive, alpha-beta T cell number,
increased neutrophil cell number,
increased plasma cell number,
increased single-positive T cell number,
increased spleen weight,
increased susceptibility to systemic lupus erythematosus
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.