klf5 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-490586

Gene Symbol: klf5 Gene Name: KLF transcription factor 5

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: klf5 assayed (1 source)
Computed annotations: klf5 assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (68 sources): abnormal Meibomian gland acinus morphology, abnormal Meibomian gland development, abnormal Meibomian gland physiology, abnormal aorta wall morphology, abnormal conjunctival epithelium morphology, abnormal corneal stroma morphology, abnormal extraocular muscle morphology, abnormal inner cell mass morphology, abnormal intestinal mucosa morphology, abnormal large intestine crypts of Lieberkuhn morphology, abnormal lens epithelium morphology, abnormal lung development, abnormal lung saccule morphology, abnormal myocardial fiber morphology, abnormal myocardial fiber physiology, abnormal ocular surface morphology, abnormal palpebral conjunctiva morphology, abnormal prostate gland anterior lobe morphology, abnormal prostate gland dorsolateral lobe morphology, abnormal prostate gland physiology, abnormal pulmonary alveolus morphology, abnormal response of heart to induced stress, abnormal response to infection, abnormal surfactant secretion, abnormal trophectoderm morphology, abnormal type I pneumocyte morphology, abnormal type II pneumocyte morphology, abnormal vascular smooth muscle physiology, abnormal vascular wound healing, absent alveolar lamellar bodies, absent blastocoele, absent conjunctiva goblet cells, cardiac fibrosis, cardiac hypertrophy, cardiac interstitial fibrosis, cardiovascular system phenotype, decreased angiogenesis, decreased corneal epithelium thickness, decreased heart weight, decreased inner cell mass proliferation, decreased prostate gland weight, decreased response of heart to induced stress, decreased trophectoderm cell proliferation, decreased type I pneumocyte number, disorganized secondary lens fibers, embryonic lethality at implantation, complete penetrance, embryonic lethality before implantation, complete penetrance, embryonic lethality, complete penetrance, enlarged hair follicles, enlarged sebaceous gland, failure of blastocyst to hatch from the zona pellucida, failure of embryo implantation, increased cell proliferation, increased corneal stroma thickness, increased heart left ventricle size, increased pulmonary respiratory rate, increased sensitivity to induced morbidity/mortality, increased sensitivity to xenobiotic induced morbidity/mortality, increased susceptibility to induced colitis, increased wet-to-dry lung weight ratio, lacrimal gland inflammation, lacrimal gland necrosis, neonatal lethality, complete penetrance, no abnormal phenotype detected, pulmonary alveolar edema, pulmonary vascular congestion, small pupils, thick lung-associated mesenchyme [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (68 sources): abnormal Meibomian gland acinus morphology, abnormal Meibomian gland development, abnormal Meibomian gland physiology, abnormal aorta wall morphology, abnormal conjunctival epithelium morphology, abnormal corneal stroma morphology, abnormal extraocular muscle morphology, abnormal inner cell mass morphology, abnormal intestinal mucosa morphology, abnormal large intestine crypts of Lieberkuhn morphology, [+]