| Monarch Ortholog Phenotypes
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Human (3 sources):
Facial flushing after alcohol intake,
Ischemic stroke,
Reduced acetaldehyde dehydrogenase level
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Mouse (31 sources):
abnormal bone mineralization,
abnormal cardiac output,
abnormal cellular respiration,
abnormal ethanol metabolism,
abnormal heart rate,
abnormal nociception after inflammation,
abnormal object recognition memory,
abnormal response to tactile stimuli,
abnormal startle reflex,
abnormal urination,
cardiac hypertrophy,
decreased CD4-positive, alpha beta T cell number,
decreased alcohol consumption,
decreased cardiac muscle contractility,
decreased circulating alkaline phosphatase level,
decreased circulating glycerol level,
decreased litter size,
decreased tumor latency,
enhanced behavioral response to alcohol,
hippocampus pyramidal cell degeneration,
hyperalgesia,
hyperpigmentation,
impaired exercise endurance,
impaired spatial learning,
increased bone mineral content,
increased hepatocyte apoptosis,
increased incidence of tumors by chemical induction,
increased sensitivity to induced cell death,
increased sensitivity to induced morbidity/mortality,
oxidative stress,
premature death
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.