tubb2b Phenotypes

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Phenotypes

Gene Literature (224)

Nucleotides (252)

Interactants (1229)

XB-GENEPAGE-491120

Gene Symbol: tubb2b Gene Name: tubulin beta 2B class IIb

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tubb2b assayed (61 sources)
Computed annotations: tubb2b assayed (8 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (49 sources): Abnormal brainstem morphology, Abnormal caudate nucleus morphology, Abnormal corpus callosum morphology, Abnormal temper tantrums, Abnormality of movement, Abnormality of the orbital region, Abnormality of vision, Agenesis of corpus callosum, Ataxia, Attention deficit hyperactivity disorder, Cataract, Cavum septum pellucidum, Cerebellar atrophy, Cerebellar hypoplasia, Cerebral palsy, Cognitive impairment, Congenital fibrosis of extraocular muscles, Cortical dysplasia, Dilation of lateral ventricles, Drooling, Dysgenesis of the basal ganglia, Focal-onset seizure, Frontoparietal cortical dysplasia, Gait disturbance, Global developmental delay, Gray matter heterotopia, Hemianopia, Hemiparesis, Hyperreflexia, Hypoplasia of the corpus callosum, Hypoplasia of the pons, Hypotonia, Infantile muscular hypotonia, Intellectual disability, Limited extraocular movements, Lissencephaly, Microcephaly, Motor delay, Oromotor apraxia, Pachygyria, Polymicrogyria, Schizencephaly, Seizure, Short stature, Skeletal muscle atrophy, Specific learning disability, Strabismus, Unilateral polymicrogyria, obsolete Frontoparietal polymicrogyria [+]
Mouse (20 sources): abnormal basal ganglion morphology, abnormal brain internal capsule morphology, abnormal brain interneuron morphology, abnormal cerebral cortex morphology, abnormal choroid plexus morphology, abnormal cortical plate morphology, abnormal neuronal precursor proliferation, abnormal primary motor cortex morphology, abnormal somatosensory cortex morphology, abnormal telencephalon morphology, absent anterior commissure, decreased midbrain size, increased neuron apoptosis, prenatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, reduced fertility, reproductive system phenotype, small cerebellum, small olfactory bulb, thin cerebral cortex [+]
View all ortholog results at Monarch