| Monarch Ortholog Phenotypes
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Human (2 sources):
Eczema,
Varicose veins
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Mouse (24 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal T cell activation,
abnormal T-helper 1 physiology,
abnormal T-helper 2 physiology,
abnormal hematopoietic system morphology/development,
abnormal immune system organ morphology,
abnormal interferon level,
abnormal lymph node B cell domain morphology,
abnormal lymphocyte physiology,
abnormal spleen germinal center morphology,
abnormal thymus involution,
craniofacial phenotype,
decreased interferon-gamma secretion,
decreased interleukin-13 secretion,
decreased interleukin-4 secretion,
decreased tumor necrosis factor secretion,
enlarged lymph nodes,
enlarged thymus,
immune system phenotype,
increased IgG1 level,
increased activated T cell number,
increased interleukin-4 secretion,
increased interleukin-5 secretion,
prenatal lethality, incomplete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.