unc93b1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (0)

XB-GENEPAGE-492942

Gene Symbol: unc93b1 Gene Name: unc-93 homolog B1, TLR signaling regulator

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: unc93b1 assayed (9 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (41 sources): abnormal T-helper 1 cell differentiation, abnormal T-helper 17 cell differentiation, abnormal antigen presentation via MHC class I, abnormal antigen presentation via MHC class II, abnormal bone marrow morphology, abnormal circulating interferon level, abnormal dendritic cell antigen presentation, abnormal dendritic cell morphology, abnormal dendritic cell physiology, abnormal macrophage physiology, abnormal tumor necrosis factor level, decreased B cell proliferation, decreased circulating interleukin-12b level, decreased circulating interleukin-6 level, decreased interferon-alpha secretion, decreased interleukin-12b secretion, decreased interleukin-6 secretion, decreased marginal zone B cell number, decreased tumor necrosis factor secretion, increased B cell proliferation, increased CD4-positive, alpha-beta memory T cell number, increased IgG2a level, increased IgG2b level, increased T-helper 1 cell number, increased T-helper 17 cell number, increased anti-nuclear antigen antibody level, increased autoantibody level, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased circulating creatinine level, increased circulating lactate dehydrogenase level, increased circulating tumor necrosis factor level, increased erythroblast number, increased interferon-alpha secretion, increased interleukin-12b secretion, increased memory T cell number, increased spleen weight, increased susceptibility to Herpesvirales infection, increased tumor necrosis factor secretion, multifocal hepatic necrosis, premature death [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (41 sources): abnormal T-helper 1 cell differentiation, abnormal T-helper 17 cell differentiation, abnormal antigen presentation via MHC class I, abnormal antigen presentation via MHC class II, abnormal bone marrow morphology, abnormal circulating interferon level, abnormal dendritic cell antigen presentation, abnormal dendritic cell morphology, abnormal dendritic cell physiology, abnormal macrophage physiology, [+]