mertk Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (122)

Interactants (3)

XB-GENEPAGE-493220

Gene Symbol: mertk Gene Name: MER proto-oncogene, tyrosine kinase

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: mertk assayed (9 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (34 sources): Abnormal electroretinogram, Abnormal retinal vascular morphology, Abnormal testis morphology, Abnormality of fundus pigmentation, Abnormality of retinal pigmentation, Anteverted nares, Atypical scarring of skin, Blindness, Cataract, Conductive hearing impairment, Constriction of peripheral visual field, Glaucoma, Hyperinsulinemia, Hyperreflexia, Hypogonadism, Hypoplasia of penis, Intellectual disability, Keratoconus, Macular atrophy, Nyctalopia, Nystagmus, Obesity, Ophthalmoplegia, Optic atrophy, Optic disc pallor, Peripheral retinal atrophy, Photophobia, Progressive night blindness, Progressive visual loss, Rod-cone dystrophy, Sensorineural hearing impairment, Type II diabetes mellitus, Visual impairment, Wide nasal bridge [+]
Mouse (31 sources): abnormal cone electrophysiology, abnormal eye electrophysiology, abnormal mononuclear cell morphology, abnormal photoreceptor outer segment morphology, abnormal retina outer nuclear layer morphology, abnormal retina photoreceptor layer morphology, abnormal retina pigment epithelium morphology, abnormal retina vasculature morphology, abnormal rod electrophysiology, abnormal tumor necrosis factor level, cardiovascular system phenotype, decreased Sertoli cell phagocytosis, decreased autoantibody level, decreased retina photoreceptor cell number, decreased susceptibility to autoimmune diabetes, decreased susceptibility to graft versus host disease, decreased susceptibility to induced thrombosis, decreased total retina thickness, disorganized photoreceptor outer segment, increased T cell apoptosis, increased circulating tumor necrosis factor level, increased retina apoptosis, increased sensitivity to induced morbidity/mortality, increased susceptibility to endotoxin shock, increased tumor necrosis factor secretion, insulitis, photoreceptor outer segment degeneration, retina photoreceptor degeneration, retina pigment epithelium atrophy, retina rod cell degeneration, thin retina outer nuclear layer [+]
View all ortholog results at Monarch