| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormal dental enamel morphology,
Abnormal form of the vertebral bodies,
Abnormal rib morphology,
Abnormality of the metaphysis,
Abnormality of the voice,
Blue sclerae,
Bowing of the long bones,
Communicating hydrocephalus,
Coronal craniosynostosis,
Crumpled long bones,
Delayed eruption of teeth,
Downslanted palpebral fissures,
Frontal bossing,
Global developmental delay,
High pitched voice,
Hydrocephalus,
Hypotonia,
Intrauterine growth retardation,
Kyphosis,
Microdontia,
Micrognathia,
Midface retrusion,
Orbital craniosynostosis,
Osteopenia,
Proptosis,
Recurrent fractures,
Scoliosis,
Shallow orbits,
Short stature,
Skeletal dysplasia,
Turricephaly,
Vertebral compression fracture,
Wormian bones,
obsolete Joint hyperflexibility
[+]
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Mouse (8 sources):
abnormal embryo size,
abnormal platelet dense granule physiology,
abnormal seminal vesicle morphology,
decreased susceptibility to induced thrombosis,
embryonic lethality prior to tooth bud stage,
hematopoietic system phenotype,
impaired neutrophil recruitment,
preweaning lethality, incomplete penetrance
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.