| Monarch Ortholog Phenotypes
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Human (30 sources):
Abnormality of immune system physiology,
Central nervous system degeneration,
Cholecystitis,
Cholelithiasis,
Chronic hemolytic anemia,
Congestive heart failure,
Decreased nerve conduction velocity,
Diaphragmatic paralysis,
Dystonia,
Generalized hypotonia,
Global developmental delay,
Hemolytic anemia,
Hypertrophic cardiomyopathy,
Hyporeflexia,
Hypotonia,
Jaundice,
Kyphosis,
Muscle weakness,
Myopathy,
Normochromic anemia,
Normocytic anemia,
Optic disc pallor,
Peripheral neuropathy,
Progressive muscle weakness,
Respiratory insufficiency due to muscle weakness,
Skeletal muscle atrophy,
Spasticity,
Splenomegaly,
Tremor,
Unsteady gait
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Mouse (13 sources):
abnormal erythropoiesis,
abnormal spleen red pulp morphology,
decreased erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased mean corpuscular hemoglobin concentration,
embryonic lethality between implantation and somite formation, complete penetrance,
increased mean corpuscular hemoglobin,
increased spleen weight,
macrocytosis,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.