| Monarch Ortholog Phenotypes
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Human (6 sources):
Carpal synostosis,
Metacarpal synostosis,
Metatarsal synostosis,
Polydactyly,
Tarsal synostosis,
Toe syndactyly
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Mouse (33 sources):
aberrant origin of the right subclavian artery,
abnormal breathing pattern,
abnormal common carotid artery morphology,
abnormal cranium morphology,
abnormal frontal bone morphology,
abnormal glomerular capillary endothelium morphology,
abnormal lung development,
abnormal lung interstitium morphology,
abnormal nasal bone morphology,
abnormal otic vesicle development,
abnormal podocyte foot process morphology,
abnormal pulmonary alveolus morphology,
abnormal renal glomerulus morphology,
abnormal rhombomere morphology,
abnormal truncus arteriosus septation,
abnormal tympanic ring morphology,
abnormal vagus nerve morphology,
decreased body size,
decreased glomerular capillary number,
decreased hematocrit,
dilated glomerular capillary,
fusion of glossopharyngeal and vagus nerve,
impaired lung alveolus development,
increased hindbrain apoptosis,
neonatal lethality, complete penetrance,
overexpanded pulmonary alveoli,
perinatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance,
retroesophageal right subclavian artery,
small lung,
small thyroid cartilage,
spinal hemorrhage,
ventricle myocardium hypoplasia
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.