| Monarch Ortholog Phenotypes
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Human (40 sources):
Abdominal pain,
Abnormal circulating enzyme concentration,
Abnormal enzyme/coenzyme activity,
Abnormal pancreatic duct morphology,
Abnormal thrombosis,
Anorexia,
Ascites,
Biliary hyperplasia,
Biliary tract obstruction,
Cholelithiasis,
Cholesterol gallstones,
Chronic pancreatitis,
Cyst of the ductus choledochus,
Decreased urine output,
Diabetes mellitus,
Elevated circulating C-reactive protein concentration,
Elevated circulating hepatic transaminase concentration,
Episodic abdominal pain,
Exocrine pancreatic insufficiency,
Fever,
Gastrointestinal dysmotility,
Hypertriglyceridemia,
Jaundice,
Leukemia,
Leukocytosis,
Lymphoma,
Nausea and vomiting,
Pancreas divisum,
Pancreatic calcification,
Pancreatic pseudocyst,
Pancreatitis,
Pleural effusion,
Recurrent pancreatitis,
Respiratory distress,
Seizure,
Sphincter of Oddi dyskinesia,
Splanchnic vein thrombosis,
Steatorrhea,
Systemic lupus erythematosus,
Type I diabetes mellitus
[+]
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Mouse (6 sources):
abnormal pancreatic acinar cell morphology,
abnormal pancreatic acinar cell physiology,
abnormal seminal vesicle morphology,
decreased circulating bilirubin level,
increased susceptibility to induced pancreatitis,
pancreas necrosis
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.