| Monarch Ortholog Phenotypes
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Human (39 sources):
Abnormal vertebral morphology,
Anteverted nares,
Blue sclerae,
Brachycephaly,
Cerebral white matter hypoplasia,
Chordee,
Clinodactyly of the 5th finger,
Constipation,
Cryptorchidism,
Delayed CNS myelination,
Delayed speech and language development,
Downslanted palpebral fissures,
Downturned corners of mouth,
Exotropia,
Feeding difficulties,
Frontal bossing,
Generalized hypotonia,
Global developmental delay,
Highly arched eyebrow,
Hypoplasia of the corpus callosum,
Hypoplastic toenails,
Joint hypermobility,
Lower limb hypertonia,
Macrocephaly,
Motor delay,
Oculomotor apraxia,
Prominent forehead,
Ptosis,
Short stature,
Short thumb,
Strabismus,
Supernumerary nipple,
Synophrys,
Syringomyelia,
Tapered finger,
Tethered cord,
Thin upper lip vermilion,
Wide nasal bridge,
Widely spaced teeth
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Mouse (45 sources):
abnormal brain wave pattern,
abnormal circadian behavior persistence,
abnormal circardian behavior entrainment,
abnormal common myeloid progenitor cell morphology,
abnormal definitive hematopoiesis,
abnormal erythropoiesis,
abnormal gastrulation,
abnormal induced morbidity/mortality,
abnormal pituitary gland development,
abnormal pituitary hormone level,
abnormal proerythroblast morphology,
absent egg cylinders,
behavior/neurological phenotype,
decreased body size,
decreased bone marrow cell number,
decreased common myeloid progenitor cell number,
decreased embryo size,
decreased erythrocyte cell number,
decreased fetal derived definitive erythrocyte cell number,
decreased granulocyte number,
decreased grip strength,
decreased growth hormone level,
decreased hematopoietic stem cell number,
decreased locomotor activity,
decreased sensitivity to xenobiotic induced morbidity/mortality,
decreased susceptibility to pharmacologically induced seizures,
decreased thyroid-stimulating hormone level,
embryonic growth arrest,
embryonic lethality between implantation and placentation, incomplete penetrance,
embryonic lethality between implantation and somite formation, complete penetrance,
embryonic lethality during organogenesis, complete penetrance,
failure to gastrulate,
increased apoptosis,
increased hematopoietic stem cell number,
lethality during fetal growth through weaning, complete penetrance,
nervous system phenotype,
pale liver,
postnatal lethality, incomplete penetrance,
prenatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
small heart,
small kidney,
small liver,
small lung,
small spleen
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.