| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormal foot morphology,
Ataxia,
Brachycephaly,
Cerebellar atrophy,
Delayed puberty,
Diabetes mellitus,
Distal muscle weakness,
Dysmetria,
Exotropia,
Failure to thrive,
Flexion contracture,
Generalized hypotonia,
Global developmental delay,
Hepatic fibrosis,
Hepatic steatosis,
Hepatomegaly,
Hip dislocation,
Hypertelorism,
Hyporeflexia,
Hypothyroidism,
Hypotonia,
Intellectual disability,
Microcephaly,
Midface retrusion,
Pancreatic fibrosis,
Progressive microcephaly,
Proximal placement of thumb,
Seizure,
Sensorineural hearing impairment,
Shawl scrotum,
Short stature,
Steatorrhea,
Talipes equinovarus,
Thin upper lip vermilion
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Mouse (17 sources):
abnormal cerebral cortex morphology,
abnormal epaxial muscle morphology,
abnormal hepatocyte morphology,
abnormal muscle fiber morphology,
abnormal pancreatic acinar cell morphology,
abnormal sarcolemma morphology,
decreased brain weight,
decreased fibroblast apoptosis,
delayed kidney development,
impaired righting response,
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.