| Monarch Ortholog Phenotypes
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Human (32 sources):
Abdominal wall muscle weakness,
Ankle flexion contracture,
Back pain,
Calf muscle hypertrophy,
Clumsiness,
Congenital finger flexion contractures,
Difficulty climbing stairs,
Elbow flexion contracture,
Elevated circulating creatine kinase concentration,
Facial palsy,
Flexion contracture,
Gait disturbance,
Generalized muscle weakness,
Hamstring contractures,
Hyperlordosis,
Increased total eosinophil count,
Lower limb muscle weakness,
Muscle fiber splitting,
Muscular dystrophy,
Myalgia,
Myopathy,
Myositis,
obsolete Difficulty walking,
obsolete Toe walking,
Pectoralis amyotrophy,
Pelvic girdle amyotrophy,
Proximal amyotrophy,
Proximal muscle weakness,
Scapular muscle atrophy,
Scapular winging,
Spinal rigidity,
Wrist flexion contracture
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Mouse (12 sources):
abnormal A band morphology,
abnormal diaphragm morphology,
abnormal gastrocnemius morphology,
abnormal sarcolemma morphology,
abnormal soleus morphology,
abnormal tibialis anterior morphology,
decreased skeletal muscle fiber diameter,
decreased skeletal muscle mass,
muscle phenotype,
no abnormal phenotype detected,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.