| Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal erythrocyte morphology,
Abnormality of the amniotic fluid,
Anemia,
Anisocytosis,
Cholecystitis,
Cholelithiasis,
Chronic hemolytic anemia,
Congenital hemolytic anemia,
Elevated transferrin saturation,
Hydrops fetalis,
Increased circulating ferritin concentration,
Increased red cell osmotic fragility,
Increased serum iron,
Intrauterine growth retardation,
Jaundice,
Nonimmune hydrops fetalis,
Poikilocytosis,
Polycythemia,
Prolonged neonatal jaundice,
Reduced erythrocyte 2,3-diphosphoglycerate concentration,
Reduced red cell pyruvate kinase level,
Reticulocytosis,
Splenomegaly,
Unconjugated hyperbilirubinemia
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Mouse (14 sources):
abnormal common myeloid progenitor cell morphology,
abnormal erythropoiesis,
decreased erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased susceptibility to parasitic infection,
decreased susceptibility to parasitic infection induced morbidity/mortality,
hemosiderosis,
increased erythroblast number,
increased erythrocyte clearance,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.