abnormal intestine physiology, abnormal iridocorneal angle, abnormal keratinocyte physiology, abnormal kidney morphology, abnormal metanephric mesenchyme morphology, abnormal metanephric ureteric bud development, abnormal nephron morphology, abnormal rete testis morphology, abnormal seminiferous tubule epithelium morphology, abnormal skin development, abnormal small intestinal crypt cell proliferation, abnormal sperm number, abnormal testis physiology, asthenozoospermia, corneal epithelium hypoplasia, decreased body size, decreased corneal epithelium thickness, decreased corneal stroma thickness, decreased epididymal cell proliferation, decreased epididymis weight, decreased fetal weight, decreased hair follicle number, decreased kidney weight, decreased liver weight, decreased renal glomerulus number, decreased retina inner nuclear layer thickness, decreased small intestinal villus size, decreased survivor rate, dilated renal tubules, dilated rete testis, disorganized retina inner nuclear layer, disorganized retina outer nuclear layer, disorganized secondary lens fibers, embryonic growth retardation, epididymis hypoplasia, eyelids open at birth, growth/size/body region phenotype, hypoplastic trabecular meshwork, impaired branching involved in ureteric bud morphogenesis, increased circulating creatinine level, increased incidence of corneal inflammation, increased kidney apoptosis, increased testis weight, lethality throughout fetal growth and development, incomplete penetrance, neonatal lethality, incomplete penetrance, perinatal lethality, complete penetrance, perinatal lethality, incomplete penetrance, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, incomplete penetrance, reduced female fertility, renal/urinary system phenotype, rete testis obstruction, retina ganglion cell degeneration, small caput epididymis, small metanephros, thin epidermis, thin retina outer nuclear layer