| Monarch Ortholog Phenotypes
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Human (35 sources):
Abnormality of the digestive system,
Abnormality of the immune system,
Airway obstruction,
Asplenia,
Asthma,
Atelectasis,
Bronchiectasis,
Chronic bronchitis,
Chronic otitis media,
Chronic sinusitis,
Clubbing of fingers,
Conductive hearing impairment,
Corneal dystrophy,
Cough,
Delayed speech and language development,
Ectopic pregnancy,
Glue ear,
Halitosis,
Headache,
Hydrocephalus,
Immotile cilia,
Impaired nasal mucociliary clearance,
Infertility,
Miscarriage,
Nasal polyposis,
Pectus excavatum,
Pneumonia,
Recurrent respiratory infections,
Reduced sperm motility,
Respiratory distress,
Rhinitis,
Scoliosis,
Situs inversus totalis,
Tachypnea,
Ventriculomegaly
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Mouse (31 sources):
abnormal craniofacial morphology,
abnormal cranium morphology,
abnormal kidney development,
abnormal locomotor activation,
abnormal lung development,
abnormal manchette morphology,
abnormal prepulse inhibition,
abnormal sperm axoneme morphology,
abnormal sperm fibrous sheath morphology,
abnormal sperm flagellum morphology,
abnormal sperm head morphology,
abnormal sperm nucleus morphology,
abnormal sperm principal piece morphology,
abnormal spermatid morphology,
absent sperm head,
decreased activated sperm motility,
decreased body length,
decreased body size,
decreased circulating glucose level,
decreased locomotor activity,
decreased sperm progressive motility,
domed cranium,
growth/size/body region phenotype,
increased prepulse inhibition,
increased susceptibility to otitis media,
postnatal lethality, complete penetrance,
postnatal lethality, incomplete penetrance,
premature death,
reproductive system phenotype,
spleen atrophy,
thymus atrophy
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.