Monarch Ortholog Phenotypes
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Human (1 source):
Sensorineural hearing impairment
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Mouse (51 sources):
abnormal CNS synaptic transmission,
abnormal Rosenthal canal morphology,
abnormal action potential,
abnormal brain wave pattern,
abnormal cell migration,
abnormal excitatory postsynaptic currents,
abnormal organ of Corti morphology,
abnormal spleen germinal center morphology,
abnormal spleen marginal zone morphology,
abnormal stria vascularis morphology,
abnormal stria vascularis vasculature morphology,
abnormal strial basal cell morphology,
abnormal strial intermediate cell morphology,
abnormal strial marginal cell morphology,
abnormal tectorial membrane morphology,
abnormal tumor morphology,
abnormal tumor vascularization,
abnormal vestibular labyrinth morphology,
abnormal vestibular system physiology,
absent distortion product otoacoustic emissions,
absent startle reflex,
cardiovascular system phenotype,
cochlear ganglion degeneration,
cochlear hair cell degeneration,
cochlear outer hair cell degeneration,
deafness,
decreased B cell apoptosis,
decreased endocochlear potential,
decreased litter size,
decreased otolith number,
detached Reissner membrane,
enlarged otoliths,
head tilt,
impaired swimming,
increased B cell derived lymphoma incidence,
increased B cell proliferation,
increased angiogenesis,
increased germinal center B cell number,
increased lung tumor incidence,
increased or absent threshold for auditory brainstem response,
increased spleen germinal center number,
increased spleen germinal center size,
increased tumor growth/size,
nervous system phenotype,
organ of Corti degeneration,
postnatal lethality, incomplete penetrance,
premature death,
small scala media,
stria vascularis degeneration,
thin stria vascularis,
vestibular saccular degeneration
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View all ortholog results at Monarch
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