| Monarch Ortholog Phenotypes
|
Human (46 sources):
Abnormal T-wave,
Abnormal spermatogenesis,
Abnormality of extrapyramidal motor function,
Anodontia,
Aplasia/Hypoplasia of the eyebrow,
Bilateral sensorineural hearing impairment,
Choreoathetosis,
Decreased response to growth hormone stimulation test,
Decreased serum estradiol,
Decreased serum insulin-like growth factor 1,
Decreased serum testosterone concentration,
Decreased testicular size,
Delayed puberty,
Delayed skeletal maturation,
Diabetes mellitus,
Dysarthria,
Dystonia,
Elevated circulating thyroid-stimulating hormone concentration,
Fine hair,
Growth delay,
Hallucinations,
Hypergonadotropic hypogonadism,
Hyperinsulinemia,
Hyperlipidemia,
Hypogonadism,
Hypogonadotropic hypogonadism,
Hypoplasia of the fallopian tube,
Hypoplasia of the uterus,
Hypothyroidism,
Insulin-resistant diabetes mellitus,
Intellectual disability,
Intellectual disability, mild,
Mental deterioration,
Micropenis,
Osteopenia,
Premature ovarian insufficiency,
Prominent nasal bridge,
Prominent nose,
Protruding ear,
Psychosis,
Scaling skin,
Sensorineural hearing impairment,
Sparse hair,
Streak ovary,
Triangular face,
obsolete Hypotrichosis
[+]
|
|
Mouse (11 sources):
abnormal acrosome morphology,
abnormal male meiosis,
abnormal manchette morphology,
abnormal sperm flagellum morphology,
abnormal sperm head morphology,
abnormal sperm midpiece morphology,
abnormal sperm nucleus morphology,
asthenozoospermia,
detached acrosome,
increased male germ cell apoptosis,
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.