| Monarch Ortholog Phenotypes
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Human (16 sources):
Abnormal bleeding,
Abnormal heart valve morphology,
Abnormal nervous system morphology,
Aortic aneurysm,
Aortic regurgitation,
Focal-onset seizure,
Gastroesophageal reflux,
Hernia,
Joint hypermobility,
Patellar dislocation,
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Mouse (33 sources):
abnormal Purkinje cell dendrite morphology,
abnormal Purkinje cell morphology,
abnormal axon extension,
abnormal axon morphology,
abnormal cerebellar foliation,
abnormal cerebral cortex morphology,
abnormal cingulate gyrus morphology,
abnormal dentate gyrus morphology,
abnormal eye development,
abnormal hindlimb morphology,
abnormal limb posture,
abnormal oculomotor nerve morphology,
abnormal parietal lobe morphology,
abnormal retina outer plexiform layer morphology,
absent hippocampal commissure,
absent subplate,
decreased body size,
decreased corpus callosum size,
decreased exploration in new environment,
decreased visual acuity,
delayed eyelid opening,
delayed hair appearance,
disorganized retina inner nuclear layer,
disorganized retina outer nuclear layer,
embryonic lethality between somite formation and embryo turning, complete penetrance,
enlarged lateral ventricles,
enlarged third ventricle,
hindlimb paralysis,
neonatal lethality, complete penetrance,
postnatal lethality, incomplete penetrance,
premature death,
reduced fertility,
unresponsive to tactile stimuli
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.