Monarch Ortholog Phenotypes
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Human (2 sources):
Cognitive impairment,
Varicose veins
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Mouse (51 sources):
abnormal anterior commissure pars posterior morphology,
abnormal bone marrow morphology,
abnormal brain internal capsule morphology,
abnormal freezing behavior,
abnormal germinal center B cell physiology,
abnormal humoral immune response,
abnormal lateral ganglionic eminence morphology,
abnormal long bone epiphyseal plate morphology,
abnormal prepulse inhibition,
abnormal startle reflex,
abnormal ventral striatum morphology,
absent B-1 B cells,
absent mature B cells,
arrested B cell differentiation,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased B-2 B cell number,
decreased IgG1 level,
decreased IgG3 level,
decreased body size,
decreased bone marrow cell number,
decreased bone mineralization,
decreased effector memory CD4-positive, alpha-beta T cell number,
decreased freezing behavior,
decreased germinal center B cell number,
decreased immature B cell number,
decreased marginal zone B cell number,
decreased pre-B cell number,
decreased prepulse inhibition,
decreased pro-B cell number,
decreased spleen germinal center number,
decreased striatum size,
decreased transitional stage B cell number,
delayed bone mineralization,
hematopoietic system phenotype,
immune system phenotype,
impaired contextual conditioning behavior,
increased B cell apoptosis,
increased B-1a cell number,
increased B-1b cell number,
increased CD4-positive, alpha beta T cell number,
increased CD8-positive, alpha-beta T cell number,
increased alpha-beta T cell number,
increased osteoblast cell number,
increased osteoclast cell number,
increased single-positive T cell number,
increased startle reflex,
increased trabecular bone thickness,
increased tumor necrosis factor secretion,
premature death,
preweaning lethality, incomplete penetrance
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View all ortholog results at Monarch
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