| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormal corpus callosum morphology,
Abnormal cortical bone morphology,
Abnormality of neuronal migration,
Agenesis of corpus callosum,
Aggressive behavior,
Decreased fetal movement,
Delayed speech and language development,
Global developmental delay,
Gray matter heterotopia,
Growth delay,
Hemiparesis,
Hyperactivity,
Hyperreflexia,
Hypoplasia of the corpus callosum,
Hypoplasia of the frontal lobes,
Impulsivity,
Intellectual disability,
Intellectual disability, severe,
Lissencephaly,
Microcephaly,
Pachygyria,
Polymicrogyria,
Schizencephaly,
Seizure,
Short stature,
Simplified gyral pattern,
Sloping forehead,
Spastic tetraparesis,
Spasticity,
Thin upper lip vermilion,
Unilateral renal agenesis,
Upslanted palpebral fissure,
Ventriculomegaly,
Vesicoureteral reflux
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Mouse (20 sources):
abnormal mitosis,
abnormal mitotic spindle assembly checkpoint,
abnormal mitotic spindle morphology,
abnormal neocortex size,
abnormal primary cilium morphology,
decreased brain size,
decreased brain weight,
decreased cell proliferation,
decreased neuronal precursor cell number,
enlarged lymph nodes,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.