vav1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-6074280

Gene Symbol: vav1 Gene Name: vav guanine nucleotide exchange factor 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: vav1 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (49 sources): abnormal CD4-positive T cell differentiation, abnormal CD4-positive, alpha beta T cell morphology, abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal CD8-positive, alpha-beta T cell physiology, abnormal T cell activation, abnormal T cell differentiation, abnormal double-negative T cell morphology, abnormal humoral immune response, abnormal interleukin-2 secretion, abnormal lymph node cell ratio, abnormal negative T cell selection, abnormal positive T cell selection, abnormal response to infection, abnormal splenic cell ratio, decreased B cell proliferation, decreased B-1 B cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased IgG1 level, decreased IgG2a level, decreased IgG3 level, decreased NK T cell number, decreased T cell proliferation, decreased double-negative T cell number, decreased double-positive T cell number, decreased interferon-gamma secretion, decreased interleukin-2 secretion, decreased interleukin-4 secretion, decreased mature B cell number, decreased single-positive T cell number, decreased thymocyte number, decreased tumor necrosis factor secretion, embryonic lethality between implantation and somite formation, complete penetrance, failure of blastocyst to hatch from the zona pellucida, immune system phenotype, impaired humoral immune response, impaired natural killer cell mediated cytotoxicity, increased DN2 thymocyte number, increased DN3 thymocyte number, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased circulating interferon-gamma level, increased double-negative T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased transitional stage B cell number, no abnormal phenotype detected, transmission ratio distortion [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (49 sources): abnormal CD4-positive T cell differentiation, abnormal CD4-positive, alpha beta T cell morphology, abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal CD8-positive, alpha-beta T cell physiology, abnormal T cell activation, abnormal T cell differentiation, abnormal double-negative T cell morphology, abnormal humoral immune response, abnormal interleukin-2 secretion, [+]