| Monarch Ortholog Phenotypes
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Human (9 sources):
Abnormality of bone marrow cell morphology,
Abnormality of the gastrointestinal tract,
Anorexia,
B-cell lymphoma,
Fatigue,
Fever,
Lymphadenopathy,
Splenomegaly,
Weight loss
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Mouse (32 sources):
Mallory bodies,
abnormal eye electrophysiology,
abnormal hepatocyte morphology,
abnormal mammary gland growth during lactation,
abnormal mammary gland growth during pregnancy,
abnormal mandible morphology,
abnormal maxilla morphology,
abnormal myocardial fiber morphology,
abnormal myocardial fiber physiology,
abnormal nursing,
behavior/neurological phenotype,
cellular phenotype,
decreased body size,
decreased total retina thickness,
disorganized retina ganglion layer,
disorganized retina layers,
endocrine/exocrine gland phenotype,
growth/size/body region phenotype,
increased heart weight,
increased hepatocellular carcinoma incidence,
increased hepatocyte apoptosis,
increased liver adenoma incidence,
increased liver weight,
lactation failure,
limb grasping,
long incisors,
no abnormal phenotype detected,
postnatal lethality, incomplete penetrance,
prenatal lethality, incomplete penetrance,
pup cannibalization,
reproductive system phenotype,
thin retina ganglion layer
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.