gdf6 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-6454243

Gene Symbol: gdf6 Gene Name: growth differentiation factor 6

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the eye (2 sources), increased apoptosis in neural progenitor cell (2 sources), abnormal development of pronephric kidney (1 source), abnormal eye morphology (1 source), abnormal pronephric kidney morphology (1 source), abnormal protein phosphorylation (1 source), abnormal retinal layer (1 source), absent amacrine cell (1 source), absent retinal ganglion cell (1 source), decreased cell population proliferation in eye (1 source), decreased size of the eye primordium (1 source), partially ventralized tadpole (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

decreased size of the eye (2 sources), increased apoptosis in neural progenitor cell (2 sources), abnormal development of pronephric kidney (1 source), abnormal eye morphology (1 source), abnormal pronephric kidney morphology (1 source), abnormal protein phosphorylation (1 source), abnormal retinal layer (1 source), absent amacrine cell (1 source), absent retinal ganglion cell (1 source), decreased cell population proliferation in eye (1 source), decreased size of the eye primordium (1 source), partially ventralized tadpole (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: gdf6 manipulated (5 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + gdf6 MO (7 sources), Xla Wt + gdf6 (2 sources), Xla Wt + gdf6 MO (1 source), Xla Wt + gdf6 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (65 sources): Abnormal cardiovascular system morphology, Abnormal cranial nerve morphology, Abnormal electroretinogram, Abnormal rib morphology, Abnormal sacrum morphology, Abnormal shoulder morphology, Abnormal temporal bone morphology, Abnormal vertebral segmentation and fusion, Abnormality of limb bone morphology, Abnormality of neuronal migration, Abnormality of retinal pigmentation, Abnormality of the kidney, Abnormality of the nervous system, Abnormality of the optic disc, Abnormality of the vertebral column, Absent testis, Anal atresia, Aplasia/Hypoplasia of the cerebellar vermis, Bilateral microphthalmos, Bimanual synkinesia, Brachydactyly, Broad foot, Cataract, Cervical C2/C3 vertebral fusion, Cervicomedullary schisis, Cleft palate, Cognitive impairment, Coloboma, Conductive hearing impairment, Congenital muscular torticollis, Ectopic anus, Encephalocele, Facial asymmetry, Global developmental delay, Hearing impairment, Hemiplegia/hemiparesis, Hypoplasia of the fovea, Hypotonia, Intellectual disability, Keratoconus, Limited neck range of motion, Low posterior hairline, Microphthalmia, Mixed hearing impairment, Nystagmus, Optic disc hypoplasia, Otosclerosis, Overlapping toe, Pes planus, Postaxial polydactyly, Posterior fossa cyst, Renal hypoplasia/aplasia, Scoliosis, Seizure, Sensorineural hearing impairment, Severely reduced visual acuity, Short neck, Spina bifida, Sprengel anomaly, Tarsal synostosis, Ultra-low vision with retained motion projection, Unilateral renal agenesis, Ventricular septal defect, Visual impairment, Webbed neck [+]
Mouse (17 sources): abnormal articular cartilage morphology, abnormal hearing physiology, abnormal incudomalleolar joint morphology, abnormal incudostapedial joint morphology, abnormal incus morphology, abnormal malleus morphology, abnormal middle ear ossicle morphology, abnormal stapes annular ligament morphology, abnormal tarsal bone morphology, absent coronal suture, absent stapes annular ligament, postnatal lethality, postnatal lethality, incomplete penetrance, small incus, small malleus, small middle ear ossicles, small stapes [+]
View all ortholog results at Monarch