| Monarch Ortholog Phenotypes
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Human (24 sources):
Abdominal pain,
Abnormal bleeding,
Abnormal hemoglobin,
Arthralgia,
Cerebral hemorrhage,
Cough,
Dyspnea,
Epistaxis,
Exertional dyspnea,
Fatigue,
Headache,
Hypertension,
Increased hematocrit,
Increased hemoglobin,
Increased red blood cell mass,
Myocardial infarction,
Peripheral thrombosis,
Plethora,
Polycythemia,
Pruritus,
Splenomegaly,
Thromboembolism,
Venous thrombosis,
Vertigo
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Mouse (33 sources):
abnormal definitive hematopoiesis,
abnormal embryonic erythrocyte morphology,
abnormal epicardium morphology,
abnormal erythropoiesis,
abnormal heart development,
abnormal heart right ventricle pressure,
abnormal interventricular groove morphology,
abnormal lung vasculature morphology,
abnormal myocardial fiber physiology,
abnormal physiological neovascularization,
abnormal placenta morphology,
abnormal postnatal subventricular zone morphology,
abnormal response to injury,
abnormal vascular endothelial cell migration,
absent erythroid progenitor cell,
decreased angiogenesis,
decreased erythrocyte cell number,
decreased hematocrit,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality, complete penetrance,
hematopoietic system phenotype,
impaired hematopoiesis,
increased hepatocyte apoptosis,
increased sensitivity to induced morbidity/mortality,
lethality throughout fetal growth and development, complete penetrance,
liver hypoplasia,
nervous system phenotype,
pale liver,
pale yolk sac,
pericardial edema,
small liver,
thick ventricular wall,
ventricular hypoplasia
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.