| Monarch Ortholog Phenotypes
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Human (3 sources):
Cataract,
Coloboma,
Microphthalmia
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Mouse (24 sources):
Harderian gland hypertrophy,
abnormal cell cycle checkpoint function,
abnormal cell death,
abnormal eye development,
abnormal gametogenesis,
abnormal hyaloid artery morphology,
abnormal lens development,
abnormal optic cup morphology,
abnormal optic fissure morphology,
abnormal optic stalk morphology,
abnormal retina development,
abnormal retina ganglion cell morphology,
abnormal retina pigment epithelium morphology,
abnormal retina progenitor cell morphology,
abnormal spinal cord interneuron morphology,
abnormal vitreous body morphology,
absent optic chiasm,
decreased eye pigmentation,
decreased total retina thickness,
disorganized retina layers,
eyelids fail to open,
lacrimal gland hypertrophy,
neonatal lethality, complete penetrance,
reproductive system phenotype
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.