cyp26a1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (145)

XB-GENEPAGE-855582

Gene Symbol: cyp26a1 Gene Name: cytochrome P450 family 26 subfamily A member 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the head (7 sources), decreased size of the cement gland (5 sources), absent eye (4 sources), abnormal development of eye (2 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: cyp26a1 manipulated (3 sources), cyp26a1 assayed (7 sources)
Computed annotations: cyp26a1 manipulated (3 sources), cyp26a1 assayed (22 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
microcephaly (5AP sources, 2 EP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + cyp26a1 + aldh1a3 MO (2 sources), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 + aldh1a2 MO (1 source), Xla Wt + cyp26a1 + DEAB (1 source), Xla Wt + cyp26a1 + DEAB (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + CHX + animal cap explant (1 source), Xla Wt + vegt + nog + cyp26a1 + CHX + animal cap explant (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + cyp26a1 + aldh1a3 MO (2 sources), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 + aldh1a2 MO (1 source), Xla Wt + cyp26a1 + DEAB (1 source), Xla Wt + cyp26a1 + DEAB (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + CHX + animal cap explant (1 source), Xla Wt + vegt + nog + cyp26a1 + CHX + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (33 sources): abnormal digestive system development, abnormal heart development, abnormal heart looping, abnormal hindbrain development, abnormal hindgut morphology, abnormal hindlimb morphology, abnormal kidney morphology, abnormal maxillary nerve morphology, abnormal mesonephros morphology, abnormal ophthalmic nerve morphology, abnormal primitive urogenital sinus morphology, abnormal reproductive system development, abnormal somite development, abnormal trigeminal ganglion morphology, abnormal urinary system development, absent tail, caudal body truncation, cervical vertebral transformation, curly tail, distended pericardium, genital tubercle hypoplasia, incomplete embryo turning, increased rhombomere 4 size, kinked tail, nervous system phenotype, no abnormal phenotype detected, open neural tube, perinatal lethality, complete penetrance, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, rhombomere transformation, short tail, vertebral transformation [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (33 sources): abnormal digestive system development, abnormal heart development, abnormal heart looping, abnormal hindbrain development, abnormal hindgut morphology, abnormal hindlimb morphology, abnormal kidney morphology, abnormal maxillary nerve morphology, abnormal mesonephros morphology, abnormal ophthalmic nerve morphology, [+]