appl1 Phenotypes

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Phenotypes

Gene Literature (7)

Nucleotides (142)

Interactants (146)

XB-GENEPAGE-855790

Gene Symbol: appl1 Gene Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: appl1 assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (24 sources): Abnormal C-peptide level, Abnormal insulin level, Abnormal oral glucose tolerance, Abnormality of the genitourinary system, Abnormality of the kidney, Elevated hemoglobin A1c, Exocrine pancreatic insufficiency, Glucose intolerance, Glycosuria, Hepatocellular adenoma, Hyperglycemia, Hyperinsulinemic hypoglycemia, Hypoinsulinemia, Insulin-resistant diabetes mellitus, Intrauterine growth retardation, Large for gestational age, Neonatal hypoglycemia, Nephropathy, Obesity, Overweight, Pancreatic hypoplasia, Renal cyst, Retinopathy, Transient neonatal diabetes mellitus [+]
Mouse (15 sources): abnormal brown adipose tissue physiology, abnormal hepatic glucose production, behavior/neurological phenotype, cellular phenotype, decreased fibroblast cell migration, decreased vasodilation, growth/size/body region phenotype, hematopoietic system phenotype, homeostasis/metabolism phenotype, immune system phenotype, increased T cell proliferation, increased core body temperature, increased fasting circulating glucose level, increased sensitivity to induced cell death, increased vasoconstriction [+]
View all ortholog results at Monarch