appl1 Phenotypes

Phenotypes

XB-GENEPAGE-855790

Gene Symbol: appl1 Gene Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (24 sources): Abnormal circulating C-peptide concentration, Abnormal circulating insulin concentration, Abnormality of the genitourinary system, Abnormality of the kidney, Abnormal oral glucose tolerance, Elevated hemoglobin A1c, Exocrine pancreatic insufficiency, Glucose intolerance, Glycosuria, Hepatocellular adenoma, Hyperglycemia, Hyperinsulinemic hypoglycemia, Hypoinsulinemia, Insulin-resistant diabetes mellitus, Intrauterine growth retardation, Large for gestational age, Neonatal hypoglycemia, Nephropathy, Obesity, Overweight, Pancreatic hypoplasia, Renal cyst, Retinopathy, Transient neonatal diabetes mellitus [+]
Mouse (15 sources): abnormal brown adipose tissue physiology, abnormal hepatic glucose production, behavior/neurological phenotype, cellular phenotype, decreased fibroblast cell migration, decreased vasodilation, growth/size/body region phenotype, hematopoietic system phenotype, homeostasis/metabolism phenotype, immune system phenotype, increased core body temperature, increased fasting circulating glucose level, increased sensitivity to induced cell death, increased T cell proliferation, increased vasoconstriction [+]
View all ortholog results at Monarch