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Summary Expression Phenotypes Gene Literature (7) GO Terms (6) Nucleotides (142) Proteins (38) Interactants (146) Wiki

appl1     adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: appl1 assayed (3 sources)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (24 sources): Abnormal C-peptide level, Abnormal insulin level, Abnormal oral glucose tolerance, Abnormality of the genitourinary system, Abnormality of the kidney, Elevated hemoglobin A1c, Exocrine pancreatic insufficiency, Glucose intolerance, Glycosuria, Hepatocellular adenoma, [+]
Mouse (15 sources): abnormal brown adipose tissue physiology, abnormal hepatic glucose production, behavior/neurological phenotype, cellular phenotype, decreased fibroblast cell migration, decreased vasodilation, growth/size/body region phenotype, hematopoietic system phenotype, homeostasis/metabolism phenotype, immune system phenotype, [+]

View all ortholog results at Monarch