| Monarch Ortholog Phenotypes
|
Human (56 sources):
Abnormal facial shape,
Abnormal pinna morphology,
Absent septum pellucidum,
Astigmatism,
Atrial septal defect,
Autistic behavior,
Bulbous nose,
Cerebral atrophy,
Cerebral visual impairment,
Chorea,
Cortical dysplasia,
Cryptorchidism,
Delayed ability to walk,
Delayed speech and language development,
Depression,
Dolichocephaly,
Downslanted palpebral fissures,
Dyskinesia,
Dystonia,
EEG with focal epileptiform discharges,
EEG with generalized epileptiform discharges,
Epileptic spasm,
Feeding difficulties,
Focal-onset seizure,
Generalized hypotonia,
Generalized-onset seizure,
Global developmental delay,
Hyperactivity,
Hypoplasia of the corpus callosum,
Hypospadias,
Hypotonia,
Hypsarrhythmia,
Impulsivity,
Intellectual disability, mild,
Intellectual disability, moderate,
Intellectual disability, severe,
Large basal ganglia,
Microcephaly,
Motor delay,
Motor stereotypy,
Multifocal epileptiform discharges,
Myopia,
Nasogastric tube feeding,
Polymicrogyria,
Poor speech,
Prominent metopic ridge,
Prominent nasal bridge,
Ptosis,
Seizure,
Short attention span,
Sleep disturbance,
Spasticity,
Square face,
Strabismus,
Thin vermilion border,
Unsteady gait
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Mouse (17 sources):
abnormal body length,
abnormal branching of the mammary ductal tree,
abnormal circulating cholesterol level,
abnormal lean body mass,
abnormal mammary gland development,
absent pinna reflex,
decreased body length,
decreased circulating amylase level,
decreased circulating estradiol level,
decreased lean body mass,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.