Monarch Ortholog Phenotypes
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Human (11 sources):
Absent speech,
Constipation,
Feeding difficulties,
Gastroesophageal reflux,
Generalized hypotonia,
Inability to walk,
Intellectual disability,
Microcephaly,
Seizure,
Strabismus,
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Mouse (28 sources):
abnormal bone mineralization,
abnormal locomotor activation,
abnormal long term depression,
abnormal long term potentiation,
abnormal nest building behavior,
abnormal object recognition memory,
abnormal prepulse inhibition,
abnormal synaptic plasticity,
abnormal voluntary movement,
behavior/neurological phenotype,
decreased anxiety-related response,
decreased body size,
decreased grip strength,
decreased locomotor activity,
decreased prepulse inhibition,
decreased thigmotaxis,
decreased vertical activity,
homeostasis/metabolism phenotype,
impaired balance,
impaired contextual conditioning behavior,
improved glucose tolerance,
increased bone mineral content,
increased lean body mass,
increased percent body fat/body weight,
nervous system phenotype,
preweaning lethality, incomplete penetrance,
reduced long term potentiation,
slow postnatal weight gain
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View all ortholog results at Monarch
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