wnk1 Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (33)

Nucleotides (304)

Interactants (112)

XB-GENEPAGE-877003

Gene Symbol: wnk1 Gene Name: WNK lysine deficient protein kinase 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: wnk1 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (41 sources): Abnormal cortical bone morphology, Abnormal hip bone morphology, Abnormality of epiphysis morphology, Abnormality of metabolism/homeostasis, Abnormality of the ankles, Abnormality of the knee, Acral ulceration, Anhidrosis, Areflexia, Autoamputation of digits, Decreased corneal reflex, Decreased nerve conduction velocity, Decreased number of peripheral myelinated nerve fibers, Decreased sensory nerve conduction velocity, Dystrophic fingernails, Dystrophic toenail, Episodic hyperhidrosis, Feeding difficulties in infancy, Foot acroosteolysis, Gastroesophageal reflux, Generalized hypotonia, Hyperchloremia, Hyperchloremic metabolic acidosis, Hyperhidrosis, Hyperkalemia, Hyperlordosis, Hypertension, Hypogeusia, Hyporeflexia, Hypotonia, Metabolic acidosis, Osteolysis, Osteolytic defects of the phalanges of the hand, Painless fractures due to injury, Paronychia, Peripheral neuropathy, Pseudohypoaldosteronism, Reduced bone mineral density, Skeletal muscle atrophy, Tapered finger, Wormian bones [+]
Mouse (33 sources): abnormal angiogenesis, abnormal brain vasculature morphology, abnormal cardinal vein morphology, abnormal distal convoluted tubule morphology, abnormal dorsal aorta morphology, abnormal placenta labyrinth morphology, abnormal placental labyrinth vasculature morphology, abnormal vascular branching morphogenesis, abnormal visceral yolk sac morphology, abnormal vitelline vascular remodeling, abnormal vitelline vasculature morphology, decreased embryo size, decreased hematocrit, decreased physiological sensitivity to xenobiotic, decreased systemic arterial blood pressure, decreased systemic arterial diastolic blood pressure, decreased systemic arterial systolic blood pressure, decreased urine sodium level, distended pericardium, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, heart hemorrhage, homeostasis/metabolism phenotype, increased circulating angiotensinogen level, increased mean systemic arterial blood pressure, increased systemic arterial diastolic blood pressure, increased systemic arterial systolic blood pressure, increased urine aldosterone level, increased urine sodium level, pale yolk sac, pericardial edema, thin myocardium, trabecula carnea hypoplasia [+]
View all ortholog results at Monarch