| Monarch Ortholog Phenotypes
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Human (13 sources):
Abnormality of the kidney,
Cataract,
Cerebellar hypoplasia,
Cryptorchidism,
Cystic renal dysplasia,
Ectopic kidney,
Global developmental delay,
Hepatomegaly,
Hyperreflexia,
Secondary microcephaly,
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Mouse (33 sources):
abnormal cellular extravasation,
abnormal cerebral cortex morphology,
abnormal cerebral cortex pyramidal cell morphology,
abnormal cranium morphology,
abnormal innervation,
abnormal leukocyte adhesion,
abnormal leukocyte physiology,
abnormal male germ cell apoptosis,
abnormal manchette morphology,
abnormal seminiferous tubule morphology,
abnormal spermatid morphology,
arrest of spermatogenesis,
cardiovascular system phenotype,
decreased fasting circulating glucose level,
decreased locomotor activity,
decreased male germ cell number,
decreased metastatic potential,
disheveled coat,
enlarged cranium,
enlarged esophagus,
immune system phenotype,
increased bone marrow cell number,
increased common myeloid progenitor cell number,
increased granulocyte number,
obstructive hydrocephaly,
perinatal lethality, incomplete penetrance,
postnatal lethality,
postnatal lethality, incomplete penetrance,
premature death,
prenatal lethality, incomplete penetrance,
preweaning lethality, incomplete penetrance,
subarachnoid hemorrhage,
thin cerebral cortex
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.