| Monarch Ortholog Phenotypes
|
Human (34 sources):
Agitation,
Akinesia,
Apathy,
Bradykinesia,
Cerebral cortical atrophy,
Chronic constipation,
Dementia,
Depression,
Diplopia,
Dyskinesia,
Dysphagia,
Dystonia,
Frequent falls,
Gliosis,
Hypomimic face,
Hyposmia,
Impulsivity,
Lewy bodies,
Low frustration tolerance,
Mental deterioration,
Monotonic speech,
Muscle spasm,
Orthostatic hypotension due to autonomic dysfunction,
Parkinsonism,
Parkinsonism with favorable response to dopaminergic medication,
Postural instability,
Resting tremor,
Rigidity,
Schizophrenia,
Shuffling gait,
Sleep disturbance,
Spastic/hyperactive bladder,
Visual hallucinations,
Weight loss
[+]
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Mouse (12 sources):
abnormal dopaminergic neuron morphology,
abnormal lysosome morphology,
abnormal small intestinal crypt cell proliferation,
alpha-synuclein inclusion body,
decreased dopamine level,
decreased locomotor activity,
decreased vertical activity,
digestive/alimentary phenotype,
embryonic lethality, complete penetrance,
loss of dopaminergic neurons,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.