| Monarch Ortholog Phenotypes
|
Human (35 sources):
Abnormal electroretinogram,
Abnormal retinal vascular morphology,
Abnormal testis morphology,
Abnormality of fundus pigmentation,
Abnormality of retinal pigmentation,
Anteverted nares,
Atypical scarring of skin,
Blindness,
Cataract,
Conductive hearing impairment,
Constriction of peripheral visual field,
Glaucoma,
Hyperinsulinemia,
Hyperreflexia,
Hypogonadism,
Hypoplasia of penis,
Intellectual disability,
Keratoconus,
Macular atrophy,
Nyctalopia,
Nystagmus,
Obesity,
Ophthalmoplegia,
Optic atrophy,
Optic disc pallor,
Photophobia,
Posterior subcapsular cataract,
Progressive night blindness,
Reduced visual acuity,
Rod-cone dystrophy,
Sensorineural hearing impairment,
Situs inversus totalis,
Type II diabetes mellitus,
Visual impairment,
Wide nasal bridge
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Mouse (29 sources):
abnormal acrosome morphology,
abnormal photoreceptor connecting cilium morphology,
abnormal photoreceptor outer segment disc membrane morphology,
abnormal photoreceptor outer segment morphology,
abnormal primary cilium morphology,
abnormal retina photoreceptor morphology,
abnormal sperm axoneme morphology,
abnormal sperm fibrous sheath morphology,
abnormal sperm flagellum morphology,
abnormal sperm head morphology,
abnormal sperm midpiece morphology,
abnormal sperm mitochondrial sheath morphology,
abnormal spermatid morphology,
abnormal spermiation,
abnormal spermiogenesis,
coiled sperm flagellum,
decreased a-wave amplitude,
decreased bone mineral content,
detached sperm flagellum,
disorganized photoreceptor outer segment,
embryonic lethality, incomplete penetrance,
enlarged lateral ventricles,
enlarged third ventricle,
immotile sperm,
increased anxiety-related response,
retina cone cell degeneration,
retina photoreceptor degeneration,
short sperm flagellum,
situs inversus
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.