rspo2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-946234

Gene Symbol: rspo2 Gene Name: R-spondin 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
wholly ventralized embryo (4 sources), abnormal foregut morphology (1 source), abnormal gastrulation (1 source), abnormal heart (1 source), abnormal heart morphology (1 source), abnormally oblique orientation of heart (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: rspo2 manipulated (16 sources), rspo2 assayed (3 sources)
Computed annotations: rspo2 assayed (22 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
visceral heterotaxy (2AP sources, 2 EP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + rspo2 MO (3 sources), Xla Wt + rspo2 MO (2 sources), Xla Wt + rspo2 MO (2 sources), Xla Wt + rspo2 MO - left (2 sources), Xla Wt + rspo2 MO - right (2 sources), Xtr Wt + nog CRISPR + rspo2 CRISPR (2 sources), Xtr Wt + rspo2 CRISPR (2 sources), Xtr Wt + rspo2 CRISPR + chrd.1 CRISPR (2 sources), Xla Wt + bmp4 + rspo2 + animal cap explant (1 source), Xla Wt + bmpr1a + rspo2 (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + rspo2 (1 source), Xla Wt + rspo2 MO (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + rspo2 MO (3 sources), Xla Wt + rspo2 MO (2 sources), Xla Wt + rspo2 MO (2 sources), Xla Wt + rspo2 MO - left (2 sources), Xla Wt + rspo2 MO - right (2 sources), Xtr Wt + nog CRISPR + rspo2 CRISPR (2 sources), Xtr Wt + rspo2 CRISPR (2 sources), Xtr Wt + rspo2 CRISPR + chrd.1 CRISPR (2 sources), Xla Wt + bmp4 + rspo2 + animal cap explant (1 source), Xla Wt + bmpr1a + rspo2 (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + rspo2 (1 source), Xla Wt + rspo2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (36 sources): Abnormal lung lobation, Abnormal rib morphology, Abnormality of the larynx, Abnormally ossified vertebrae, Agenesis of corpus callosum, Anal atresia, Ankyloglossia, Aplasia/Hypoplasia involving the nose, Aplasia/Hypoplasia involving the pelvis, Aplasia/Hypoplasia of the lungs, Aplasia/Hypoplasia of the nipples, Bilateral cleft lip, Cataract, Cryptorchidism, Glossoptosis, Hydrocephalus, Hypoplastic pulmonary veins, Iris coloboma, Low-set ears, Microcornea, Micrognathia, Micropenis, Microphthalmia, Microretrognathia, Microtia, Missing ribs, Multicystic kidney dysplasia, Narrow mouth, Optic atrophy, Orofacial cleft, Polyhydramnios, Septo-optic dysplasia, Tetraamelia, Tracheal stenosis, Vaginal atresia, Ventricular septal defect [+]
Mouse (43 sources): abnormal apical ectodermal ridge morphology, abnormal digestive system development, abnormal forelimb morphology, abnormal forelimb zeugopod morphology, abnormal hindlimb morphology, abnormal kidney development, abnormal laryngeal cartilage morphology, abnormal limb development, abnormal limb morphology, abnormal lung vasculature morphology, abnormal mandibular angle morphology, abnormal maxilla morphology, abnormal maxillary shelf morphology, abnormal maxillary zygomatic process morphology, abnormal nail morphology, abnormal ovulation, abnormal palatal shelf elevation, abnormal palatal shelf fusion at midline, abnormal phalanx morphology, abnormal pharyngeal arch mesenchyme morphology, abnormal pulmonary alveolus morphology, abnormal temporal bone squamous part morphology, abnormal tooth development, abnormal tracheal cartilage morphology, abnormal zygomatic bone morphology, absence of all nails, absent mandibular coronoid process, arytenoid and cricoid cartilage fusion, decreased palatine bone horizontal plate size, decreased tympanic ring size, delayed kidney development, growth retardation of incisors, lung hemorrhage, maxillary shelf hypoplasia, neonatal lethality, complete penetrance, palatal shelves fail to meet at midline, perinatal lethality, complete penetrance, reduced female fertility, short Meckel's cartilage, short mandible, small mandible, small mandibular condyloid process, small maxilla [+]
View all ortholog results at Monarch