Generalized hypotonia, Global developmental delay, Hypotonia, Hypsarrhythmia, Infantile spasms, Intellectual disability, Microcephaly, Myoclonus, Myopia, Seizure, Spasticity

abnormal learning/memory/conditioning, abnormal long term depression, abnormal long term object recognition memory, abnormal miniature excitatory postsynaptic currents, abnormal object recognition memory, abnormal operant conditioning behavior, abnormal social investigation, abnormal spatial learning, abnormal spatial reference memory, abnormal spatial working memory, abnormal suckling behavior, abnormal synapse morphology, abnormal temporal memory, absence of NMDA-mediated synaptic currents, absent gastric milk in neonates, absent long term depression, absent suckling reflex, behavior/neurological phenotype, decreased anxiety-related response, decreased body size, decreased physiological sensitivity to xenobiotic, disorganized barrel cortex, enhanced contextual conditioning behavior, enhanced cued conditioning behavior, enhanced long term potentiation, fast extinction of fear memory, impaired swimming, impaired synaptic plasticity, increased prepulse inhibition, increased startle reflex, increased thigmotaxis, neonatal lethality, complete penetrance, nervous system phenotype, perinatal lethality, complete penetrance, postnatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, reduced long term depression, reduced long term potentiation, social withdrawal