hcn1 Phenotypes

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Phenotypes

Gene Literature (65)

Nucleotides (60)

Interactants (75)

XB-GENEPAGE-950264

Gene Symbol: hcn1 Gene Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (73 sources): Abnormal corpus callosum morphology, Abnormal involuntary eye movements, Abnormal myelination, Abnormality of coordination, Abnormality of vision, Anxiety, Ataxia, Atonic seizure, Attention deficit hyperactivity disorder, Atypical absence status epilepticus, Autism, Autistic behavior, Behavioral abnormality, Bilateral tonic-clonic seizure, Bradykinesia, Brain atrophy, Cerebral atrophy, Cognitive impairment, Cortical dysplasia, Decreased fetal movement, Delayed speech and language development, Developmental regression, Difficulty walking, Downslanted palpebral fissures, Dyskinesia, EEG with multifocal slow activity, EEG with spike-wave complexes, Encephalopathy, Epileptic encephalopathy, Failure to thrive, Febrile seizure (within the age range of 3 months to 6 years), Feeding difficulties, Focal impaired awareness seizure, Focal-onset seizure, Gastroesophageal reflux, Generalized cerebral atrophy/hypoplasia, Generalized hypotonia, Generalized myoclonic seizure, Generalized non-motor (absence) seizure, Generalized-onset seizure, Global developmental delay, High forehead, Hypodontia, Hyporeflexia, Hypotonia, Hypsarrhythmia, Impulsivity, Incoordination, Intellectual disability, Involuntary movements, Limb hypertonia, Limited knee extension, Mental deterioration, Microcephaly, Myoclonus, Nystagmus, Obsessive-compulsive trait, Optic atrophy, Pes planus, Poor fine motor coordination, Poor head control, Ptosis, Reduced tendon reflexes, Retinal degeneration, Rigidity, Seizure, Short stature, Spasticity, Status epilepticus, Talipes valgus, Tibial torsion, Tremor, Unsteady gait [+]
Mouse (22 sources): abnormal QT interval, abnormal RR interval, abnormal action potential, abnormal depression-related behavior, abnormal eye blink conditioning behavior, abnormal heart rate, abnormal heartbeat, abnormal learning/memory/conditioning, abnormal locomotor behavior, abnormal motor learning, abnormal myocardial fiber physiology, abnormal pain threshold, abnormal sinoatrial node conduction, abnormal spatial learning, behavior/neurological phenotype, decreased cardiac output, decreased locomotor activity, increased heart rate variability, increased heart weight, increased thigmotaxis, no abnormal phenotype detected, prolonged RR interval [+]
View all ortholog results at Monarch