ezh2 Phenotypes

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Phenotypes

Gene Literature (41)

Nucleotides (355)

Interactants (614)

XB-GENEPAGE-956214

Gene Symbol: ezh2 Gene Name: enhancer of zeste 2 polycomb repressive complex 2 subunit

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (78 sources): Abnormal cardiovascular system morphology, Abnormal fingernail morphology, Abnormality of the metaphysis, Abnormally low-pitched voice, Absent septum pellucidum, Accelerated skeletal maturation, Behavioral abnormality, Broad foot, Broad forehead, Broad thumb, Calcaneovalgus deformity, Camptodactyly, Camptodactyly of finger, Clinodactyly, Coxa valga, Cryptorchidism, Cutis laxa, Deep philtrum, Deep-set nails, Delayed speech and language development, Depressed nasal bridge, Diastasis recti, Dilation of lateral ventricles, Dimple chin, Downslanted palpebral fissures, Dysarthria, Dysharmonic skeletal maturation, Epicanthus, Feeding difficulties in infancy, Fine hair, Finger syndactyly, Flared femoral metaphysis, Flared humeral metaphysis, Generalized hypotonia, Global developmental delay, Hoarse voice, Hydrocele testis, Hypertelorism, Hypoplasia of penis, Hypoplastic iliac wing, Hypoplastic toenails, Hypotonia, Intellectual disability, Inverted nipples, Joint contracture of the hand, Joint stiffness, Kyphosis, Large hands, Limited elbow extension, Limited knee extension, Long philtrum, Low-set, posteriorly rotated ears, Macrocephaly, Macrotia, Mandibular prognathia, Metatarsus adductus, Micrognathia, Overlapping toe, Pes cavus, Prominent fingertip pads, Radial deviation of finger, Redundant skin, Retrognathia, Round face, Sandal gap, Scoliosis, Seizure, Short fourth metatarsal, Short ribs, Slurred speech, Sparse hair, Spasticity, Strabismus, Talipes equinovarus, Tall stature, Thin nail, Umbilical hernia, obsolete Joint hyperflexibility [+]
Mouse (45 sources): abnormal embryonic tissue morphology, abnormal extraembryonic tissue morphology, abnormal immunoglobulin V(D)J recombination, abnormal neuron differentiation, abnormal pro-B cell morphology, abnormal spleen white pulp morphology, absent inner cell mass proliferation, behavior/neurological phenotype, decreased B cell proliferation, decreased IgG1 level, decreased IgG2b level, decreased IgG3 level, decreased double-positive T cell number, decreased embryo size, decreased germinal center B cell number, decreased immature B cell number, decreased pre-B cell number, decreased spleen germinal center number, decreased spleen germinal center size, decreased thymocyte number, embryonic growth arrest, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality between somite formation and embryo turning, complete penetrance, embryonic lethality, complete penetrance, enlarged lymph nodes, failure to gastrulate, immune system phenotype, increased B cell derived lymphoma incidence, increased double-negative T cell number, increased germinal center B cell number, increased growth rate, increased heart weight, increased kidney weight, increased mean corpuscular hemoglobin, increased sacral vertebrae number, increased spleen germinal center number, increased spleen germinal center size, increased spleen weight, no abnormal phenotype detected, perinatal lethality, complete penetrance, premature death, prenatal lethality, complete penetrance, primary atelectasis, thin myocardium compact layer [+]
View all ortholog results at Monarch