itk Phenotypes

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Phenotypes

Gene Literature (59)

Nucleotides (47)

Interactants (561)

XB-GENEPAGE-957719

Gene Symbol: itk Gene Name: IL2-inducible T cell kinase

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (13 sources): Anemia, Autoimmunity, Decreased circulating IgG concentration, Elevated erythrocyte sedimentation rate, Hepatomegaly, Lymphadenopathy, Lymphoma, Pancytopenia, Recurrent aphthous stomatitis, Recurrent infections, Splenomegaly, Stomatitis, Thrombocytopenia [+]
Mouse (32 sources): abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal CD8-positive, alpha-beta T cell physiology, abnormal cell proliferation, abnormal gamma-delta T cell morphology, abnormal NK T cell morphology, abnormal positive T cell selection, abnormal T cell activation, abnormal thymus cell ratio, decreased CD4-positive, alpha beta T cell number, decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased CD8-positive, alpha-beta memory T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased interferon-gamma secretion, decreased interleukin-2 secretion, decreased NK T cell number, decreased T cell proliferation, immune system phenotype, increased CD8-positive, alpha-beta memory T cell proliferation, increased CD8-positive, alpha-beta T cell number, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased double-negative T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased germinal center B cell number, increased interferon-gamma secretion, increased interleukin-10 secretion, increased interleukin-13 secretion, increased interleukin-4 secretion, increased mature gamma-delta T cell number, increased memory T cell number, increased susceptibility to parasitic infection [+]
View all ortholog results at Monarch