| Monarch Ortholog Phenotypes
|
Human (21 sources):
Aggressive behavior,
Apraxia,
Broad nasal tip,
Delayed ability to walk,
Delayed gross motor development,
Delayed myelination,
Delayed speech and language development,
Downslanted palpebral fissures,
Generalized hypotonia,
Hyperactivity,
Hypertelorism,
Intellectual disability,
Macrocephaly,
Motor stereotypy,
Nystagmus,
Obesity,
Open mouth,
Prominent forehead,
Retrognathia,
Short nose,
Strabismus
[+]
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Mouse (28 sources):
abnormal T cell activation,
abnormal adipose tissue amount,
abnormal cardiac outflow tract development,
abnormal fetal cardiomyocyte proliferation,
abnormal heart development,
abnormal lean body mass,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal sarcomere morphology,
arrested B cell differentiation,
cardiovascular system phenotype,
conotruncal ridge hyperplasia,
decreased CD4-positive, alpha beta T cell number,
decreased mature B cell number,
disorganized myocardium,
immune system phenotype,
increased T cell apoptosis,
increased atrioventricular cushion size,
increased fetal cardiomyocyte proliferation,
increased lean body mass,
lethality throughout fetal growth and development, complete penetrance,
lethality throughout fetal growth and development, incomplete penetrance,
neonatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
thick interventricular septum,
thick ventricular wall,
thin ventricle myocardium compact layer,
thin ventricular wall
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.