cdk8 Phenotypes

Phenotypes

XB-GENEPAGE-962266

Gene Symbol: cdk8 Gene Name: cyclin-dependent kinase 8

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: cdk8 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (14 sources): abnormal embryo size, abnormal embryo turning, abnormal pancreatic beta cell physiology, abnormal preimplantation embryo development, abnormal tail bud morphology, decreased pancreatic beta cell mass, embryonic lethality before implantation, complete penetrance, failure of morula compaction, improved glucose tolerance, increased cellular sensitivity to oxidative stress, increased circulating glucose level, increased insulin secretion, increased pancreatic beta cell apoptosis, preweaning lethality, complete penetrance [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (14 sources): abnormal embryo size, abnormal embryo turning, abnormal pancreatic beta cell physiology, abnormal preimplantation embryo development, abnormal tail bud morphology, decreased pancreatic beta cell mass, embryonic lethality before implantation, complete penetrance, failure of morula compaction, improved glucose tolerance, increased cellular sensitivity to oxidative stress, [+]