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XB-GENEPAGE-962773
nek2 NIMA-related kinase 2
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| abnormally decreased number of cilium in the left-right organizer (5 sources), abnormal heart looping (4 sources), abnormal determination of left/right symmetry (2 sources), abnormal determination of left/right symmetry in lateral plate mesoderm (2 sources), obsolete decreased cilium motility in ciliated epidermal cell (2 sources), abnormally decreased number of cilium in the multiciliated epidermal cell (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: nek2 manipulated (5 sources) |
| Computed annotations: nek2 assayed (3 sources) |
| Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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| visceral heterotaxy (16AP sources, 5 EP sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xtr Wt + nek2 MO (7 sources), Xtr Wt + Hsa.NEK2 (5 sources), Xtr Wt + nek2 MO (2 sources), Xtr Wt + nek2 MO (2 sources), Xtr Wt + Hsa.NEK2 (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Human (30 sources): Abnormal electroretinogram, Abnormal retinal vascular morphology, Abnormal testis morphology, Abnormality of fundus pigmentation, Abnormality of retinal pigmentation, Anteverted nares, Atypical scarring of skin, Blindness, Cataract, Conductive hearing impairment, [+] |
| Mouse (3 sources): abnormal kidney morphology, abnormal locomotor behavior, enlarged lymph nodes |
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View all ortholog results at Monarch |