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Summary Expression Phenotypes Gene Literature (28) GO Terms (7) Nucleotides (364) Proteins (38) Interactants (241) Wiki

top2a     DNA topoisomerase II alpha

Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: top2a assayed (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (7 sources): abnormal circulating alkaline phosphatase level, abnormal embryo size, abnormal hematocrit, embryonic lethality prior to organogenesis, increased circulating alkaline phosphatase level, prenatal lethality prior to heart atrial septation, preweaning lethality, complete penetrance