rbl1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (11)

XB-GENEPAGE-976493

Gene Symbol: rbl1 Gene Name: retinoblastoma-like 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
neoplastic eye (12 sources), increased cell population proliferation in retina (4 sources), abnormally localised blood vessel (3 sources), increased size of the eye (3 sources), abnormal brain morphology (2 sources), increased cell population proliferation in brain (2 sources), neoplastic lung (2 sources), abnormal brain ventricle morphology (1 source), abnormal midbrain morphology (1 source), abnormal optic nerve morphology (1 source), abnormal pancreas morphology (1 source), abnormal retina morphology (1 source), abnormally localised lens (1 source), abnormally necrotic retina (1 source), increased cell population proliferation in adipose tissue (1 source), increased cell population proliferation in midbrain (1 source), increased cell population proliferation in optic nerve (1 source), neoplastic brain (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

neoplastic eye (12 sources), increased cell population proliferation in retina (4 sources), abnormally localised blood vessel (3 sources), increased size of the eye (3 sources), abnormal brain morphology (2 sources), increased cell population proliferation in brain (2 sources), neoplastic lung (2 sources), abnormal brain ventricle morphology (1 source), abnormal midbrain morphology (1 source), abnormal optic nerve morphology (1 source), abnormal pancreas morphology (1 source), abnormal retina morphology (1 source), abnormally localised lens (1 source), abnormally necrotic retina (1 source), increased cell population proliferation in adipose tissue (1 source), increased cell population proliferation in midbrain (1 source), increased cell population proliferation in optic nerve (1 source), neoplastic brain (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: rbl1 assayed (3 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
retinoblastoma (12AP sources), glioblastoma (2AP sources), choroid plexus cancer (1AP source), medulloblastoma (1AP source), pancreatic cancer (1AP source), pineoblastoma (1AP source), trilateral retinoblastoma (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + rb1 CRISPR + rbl1 CRISPR (15 sources), Xtr Wt + rbl1 CRISPR + rb1 CRISPR (3 sources), Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR (1 source), Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR + pten CRISPR (1 source), Xtr.tp53em_del1/em_del2_Vlemx + rb1 CRISPR + rbl1 CRISPR (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (40 sources): abnormal amacrine cell morphology, abnormal common myeloid progenitor cell morphology, abnormal cone electrophysiology, abnormal definitive hematopoiesis, abnormal eye development, abnormal kidney morphology, abnormal mean corpuscular volume, abnormal neuronal precursor proliferation, abnormal postnatal subventricular zone morphology, abnormal retina bipolar cell morphology, abnormal retina inner nuclear layer morphology, abnormal retina inner plexiform layer morphology, abnormal rod electrophysiology, abnormal spleen red pulp morphology, abnormal white adipose tissue morphology, cellular phenotype, decreased body size, decreased gonadal fat pad weight, decreased inguinal fat pad weight, decreased interscapular fat pad weight, decreased mean corpuscular volume, decreased percent body fat/body weight, decreased retina ganglion cell number, decreased retina rod cell number, decreased total fat pad weight, decreased white adipose tissue amount, decreased white fat cell size, improved glucose tolerance, increased bone marrow cell number, increased cell proliferation, increased diameter of long bones, increased fibroblast proliferation, increased neuronal precursor cell number, increased oxygen consumption, integument phenotype, no abnormal phenotype detected, postnatal lethality, incomplete penetrance, premature death, preweaning lethality, incomplete penetrance, thin retina outer nuclear layer [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (40 sources): abnormal amacrine cell morphology, abnormal common myeloid progenitor cell morphology, abnormal cone electrophysiology, abnormal definitive hematopoiesis, abnormal eye development, abnormal kidney morphology, abnormal mean corpuscular volume, abnormal neuronal precursor proliferation, abnormal postnatal subventricular zone morphology, abnormal retina bipolar cell morphology, [+]