| Monarch Ortholog Phenotypes
|
Human (51 sources):
Abdominal pain,
Abnormal bleeding,
Abnormal dental enamel morphology,
Abnormal hair morphology,
Abnormality of the optic nerve,
Abnormality of thrombocytes,
Abnormality of visual evoked potentials,
Albinism,
Amblyopia,
Anorexia,
Astigmatism,
Basal cell carcinoma,
Blindness,
Bruising susceptibility,
Cardiomyopathy,
Cataract,
Colitis,
Dyspnea,
Epistaxis,
Fatigue,
Freckles in sun-exposed areas,
Freckling,
Gastrointestinal hemorrhage,
Gingival bleeding,
Hematochezia,
Hyperkeratosis,
Hypopigmentation of hair,
Hypopigmentation of the skin,
Immunodeficiency,
Inflammation of the large intestine,
Iris hypopigmentation,
Long eyelashes,
Malabsorption,
Melanocytic nevus,
Menometrorrhagia,
Myopia,
Neutropenia,
Nystagmus,
Ocular albinism,
Partial albinism,
Photophobia,
Prolonged bleeding time,
Pulmonary fibrosis,
Renal insufficiency,
Restrictive ventilatory defect,
Severely reduced visual acuity,
Squamous cell carcinoma of the skin,
Strabismus,
Thickened skin,
Visual impairment,
Weight loss
[+]
|
Mouse (21 sources):
abnormal choroid pigmentation,
abnormal ciliary body pigmentation,
abnormal ear pigmentation,
abnormal macrophage physiology,
abnormal melanosome morphology,
abnormal type II pneumocyte morphology,
alveolitis,
decreased ear pigmentation,
decreased eye pigmentation,
decreased platelet ADP level,
decreased platelet ATP level,
decreased platelet dense granule number,
decreased platelet serotonin level,
decreased tail pigmentation,
diluted coat color,
enlarged alveolar lamellar bodies,
increased lysosomal enzyme secretion,
increased susceptibility to atherosclerosis,
overexpanded pulmonary alveoli,
perinatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.