wfs1 Phenotypes

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Phenotypes

Gene Literature (4)

Nucleotides (129)

Interactants (543)

XB-GENEPAGE-978819

Gene Symbol: wfs1 Gene Name: Wolfram syndrome 1 (wolframin)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: wfs1 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (75 sources): Abnormal autonomic nervous system physiology, Abnormal pinna morphology, Abnormality of mesentery morphology, Abnormality of the upper urinary tract, Abnormality of the urinary system, Anemia, Anxiety, Ataxia, Autism, Autistic behavior, Behavioral abnormality, Cardiomyopathy, Central apnea, Central diabetes insipidus, Cerebral atrophy, Cerebral cortical atrophy, Congenital sensorineural hearing impairment, Constipation, Delayed puberty, Dementia, Depression, Developmental regression, Diabetes insipidus, Diabetes mellitus, Dysarthria, Dysphagia, Dysuria, Feeding difficulties in infancy, Gastric ulcer, Gastrointestinal dysmotility, Gastrointestinal hemorrhage, Glaucoma, Glucose intolerance, Growth delay, Hallucinations, Hearing impairment, Hydronephrosis, Hydroureter, Hypogonadism, Hypothyroidism, Impaired glucose tolerance, Intellectual disability, Joint stiffness, Limited mobility of proximal interphalangeal joint, Low-frequency sensorineural hearing impairment, Malabsorption, Male hypogonadism, Megaloblastic anemia, Myopathy, Nephropathy, Neurogenic bladder, Nystagmus, Ophthalmoplegia, Optic atrophy, Peripheral axonal neuropathy, Peripheral neuropathy, Pigmentary retinopathy, Polydipsia, Primary gonadal insufficiency, Progressive cerebellar ataxia, Progressive sensorineural hearing impairment, Psychosis, Ptosis, Recurrent urinary tract infections, Respiratory insufficiency, Schizophrenia, Seizure, Sensorineural hearing impairment, Severe postnatal growth retardation, Sideroblastic anemia, Sleep disturbance, Stroke-like episode, Testicular atrophy, Thrombocytopenia, Tremor [+]
Mouse (37 sources): abnormal associative learning, abnormal behavioral response to addictive substance, abnormal blood homeostasis, abnormal cued conditioning behavior, abnormal defecation, abnormal pancreas secretion, abnormal pancreatic beta cell physiology, abnormal pancreatic islet morphology, abnormal social investigation, abnormal spatial learning, abnormal thyroid follicle morphology, abnormal vocalization, analgesia, behavior/neurological phenotype, decreased body size, decreased circulating glucose level, decreased exploration in new environment, decreased food intake, decreased insulin secretion, decreased locomotor activity, decreased pancreatic beta cell mass, decreased vertical activity, disorganized pancreatic islets, enhanced active avoidance behavior, enhanced passive avoidance behavior, impaired behavioral response to addictive substance, impaired swimming, increased anxiety-related response, increased circulating glucose level, increased circulating insulin-like growth factor I level, increased coping response, increased glucagon secretion, increased oxygen consumption, increased thigmotaxis, increased vertical activity, prenatal lethality, incomplete penetrance, slow postnatal weight gain [+]
View all ortholog results at Monarch